Randy Schekman (HHMI & UCB) 1: Secretory Pathway: How cells package & traffic proteins for export

Randy Schekman explains how cells use the endoplasmic reticulum, Golgi apparatus, and transport vesicles to package and secrete proteins; tracing discoveries from Palade’s microscopy and Blobel’s signal hypothesis to yeast genetics that uncovered the molecular machinery driving secretion.